Ethical judgment is not a definitive restriction on the method and production of knowledge in the field of art, but it relatively limits the production of knowledge in the fields of natural sciences. Because ethical judgment is an authority in the conception and mind of most people, people tend to follow ethical standards and have more difficulty developing further knowledge. Furthermore, reason is one of the ways of knowing, and moral principle is a crucial factor that shapes the pursuit of knowledge. Extreme cases in the natural sciences and in particular areas of knowledge violate reason which undermines moral obligation. There are numerous examples that demonstrate that extreme cases in science, such as scientific experimentation resulting in the fatal killing of human beings, are controversial to the public and society as a whole. Good morality or fairness and ethical judgment potentially prevent people from finding advanced knowledge and circumscribe the process and method of knowledge as a result of public opinion and moral dilemmas. However, some artists receive great attention and express their concepts more effectively by challenging ethical judgment in works of art, which reveals that ethical judgment and moral principle expand the available methods in producing knowledge in the field of art . For science in the arts In the field of knowledge, the human brain sampling experiment is an ideal experiment for hormone research and a very representative example of the assertion that ethical judgments relatively limit the methods available in the production of knowledge in natural sciences. If the experiment is successful, it will help scientists have a better understanding of medical and scientific science...... half of the article ...... Cited1. History of Medicine: Subjected to Science: Human Experimentation in America Before World War II, Annals of Internal Medicine, American College of Physicians, July 15, 1995 vol. 123 n. 2 1592. Presidential Commission for the Study of Ethical Problems in Medicine, Biomedicine, and Behavioral Research, "Defining Death: Medical, Legal, and Ethical Issues in the Determination of Death," July 1981.3. Vaughan, R. M. (04-14-2007). "Boundaries still breaking after all these years; the monstrous and the banal collide in a massive investigation of Carolee Schneemann's taboo-breaking art." The globe and the mail. P. R18.4. Cézanne, She was a great painter as cited in Semmel, Joan; April Kingsley. "Sexual Imagery in Women's Art." Women's Art Diary 1 (1): p. 6.JSTOR1358010.5. Newman, Amy (02-03-2002). "An innovator who was the eros of his own art." New York Times.