INTRODUCTION In recent years, platinum-based drugs have been considered a hallmark of cancer chemotherapy due to their remarkable success in treating a wide variety of types of cancer. The most significant and commonly used form of platinum-based drugs is cisplatin. Although treatment with cisplatin has been successful on many occasions, its broad mode of action and overuse have led to toxic side effects in patients, as well as increased drug resistance in some tumor cells.1 For these reasons combined , scientists have redirected their investigations to other metal-based drugs in an effort to find potential alternatives that can overcome cisplatin resistance and reduce the severity of toxic side effects. Gold has been one of the best choices of alternative metals to study due to its established reputation in medicinal applications throughout history. In the treatment of rheumatoid arthritis, gold-based drugs have been used for a long time showing remarkable results. Its immunosuppressive and anti-inflammatory characteristics manifested in rheumatoid arthritis patients linked its potential benefits in the treatment of cancer.2 Gold was also a popular choice among other metals due to its similarity in geometric structure and being isoelectronic with cisplatin.1 With these upcoming characteristics in hand, gold seemed like a reasonable candidate for this investigation.CHARACTERISTICS OF GOLD COMPLEXESGold complexes in the oxidative state +I and +III are the two main forms of gold complexes used in cancer chemotherapy. Gold(I) complexes are comparable to the current leading rheumatoid arthritis drug auranofin in its structure as well as maintaining its immunosuppressive and anti-inflammatory characteristics....... half of the article...... rd RT Gold Derivatives For the Treatment of Cancer. Hematology oncology. 2002, 42, 225-248.[3] Oct, Ingo. On the medicinal chemistry of gold complexes as anticancer drugs. Coord. Chemistry. Rev. 2009, 253, 1670-1681.[4] Gabbiani, Chiara; Cinellu, Maria Agostina, Maiore, Laura; Scaletti, Federica; Messori, Luigi. Chemistry and biology of three representative gold(III) compounds as potential anticancer agents. Inorg. Chem., 2012, 393, 115-124[5] Rigobella, Maria Pia; Messori, Luigi; Marcon, Giordana. Gold complexes inhibit mitochondrial thioredoxin reductase: consequences for mitochondrial functions. J. Inorg. Biochemistry. 2004, 98, 1634-1641.[6] Palanichamy, Kamalakannan; Sreejayan, Nair; Onko, Allyn. Overcoming cisplatin resistance using gold(III) mimics: antitumor activity of novel gold(III) polypyridyl complexes. J. Inorg. Biochemistry. 2012, 106, 32-42.